#$%^&*AU2020101155A420200730.pdf#####ABSTRACT An acid-resistant and sustained-release oral crystal ball containing probiotics is disclosed herein. It comprises a spherical core for 5 accommodating probiotics, a protection layer wrapped around the spherical core, a sustained-release layer wrapped around the protection layer, a bile salt and pancreatic juice resistant layer wrapped around the sustained-release layer, an acid-resistant layer wrapped around the bile salt and pancreatic juice resistant layer, and an insulation layer wrapped 10 around the acid-resistant layer.
