The invention relates to a use of herbal medicine for preparing a drug for treatment or inhibition of degenerative brain diseases, in which the herbal medicine comprises: a first herbal formula, which comprises 2-40 part by weight of Panax ginseng and 0.6-28 part by weight of Angelica sinensis and a second herbal formula which comprises 0.6-28 part by weight of Angelica sinensis, 2-40 part by weight of Astragalus membranaceus and 20-96 part by weight of a mixture containing of Ligustri fructus, Eclipta prostrata and Rehmannia glutinosa.本發明提供一種中草藥組成物用於製備治療或抑制腦部退化相關疾病藥物之用途,該中草藥組成物包括:一第一藥材,其係包含2-40重量份之人參及0.6-28重量份之當歸;以及一第二藥材,其係包含0.6-28重量份之當歸、2-40重量份之黃耆、以及20-96重量份之女貞子、旱蓮草及地黃之混合物。