Blood-brain barrier transmigrating compounds and uses thereof

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专利权人:

National Research Council of Canada

发明人:

Chakravarthy, Balu,Stanimirovic, Danica,Durocher, Yves

申请号：

AU2018212860

公开号：

AU2018212860A1

申请日:

2018.01.30

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

A brain-penetrating composition of amyloid-ß binding peptide is disclosed. This may be useful in the treatment of Alzheimer's disease, for example as a bifunctional molecule, comprising a blood-brain barrier crossing antibody and an amyloid-ß targeting peptide linked via an Fc fragment that is able to transmigrate across the blood-brain barrier into the brain, and compositions comprising same. Methods of using this composition for treating Alzheimer's disease are disclosed.

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