IDENTIFICATION D'AGONISTES PEPTIDIQUES CYCLIQUES DU RÉCEPTEUR 2 ET 3 DE GALANINE GUIDÉS PAR UNE STRUCTURE DE SOLUTION DE SPEXINE

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专利权人:

Hong Kong Baptist University

发明人:

申请号：

EP18780453.9

公开号：

EP3606948A1

申请日:

2018.03.23

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Cyclic peptide agonists toward human galanin receptor 2 (GalR2) and galanin receptor 3 (GalR3) based on hidden conformation of spexin solution structure for GalR2 and GalR3-related and spexin-deficient disorders are designed and synthesized. LH101, LH102, and LH101 (Ac) are potent spexin analogs with prolonged action, which can be used in the treatment of GalR2 and GalR3-related diseases and spexin-deficient disorders, such as obesity.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/