Use of Phthalides in The Preparation of Medicinal Composition for Treating Alzheimer’s Disease And 2,3-Biphosphoglycerate Metabolism Disorder Induced Morbidities
The present invention relates to a use of phthalides in the preparation of medicinal composition for treating Alzheimer’s disease and 2,3-biphosphoglycerate (2,3-BPG) metabolism disorder induced morbidities, wherein the phthalides can play a role similar to 2,3-BPG in modulating the hemoglobin allostery to lower the oxygen affinity, and can therefore act as the 2,3-BPG substitute to maintain the normal oxygen release function of hemoglobin and the normal cellular oxygenation level for patients with Alzheimer’s disease and 2,3-BPG metabolism disorder induced morbidities whose 2,3-BPG becomes too low to fulfill the cellular oxygen requirements.本發明係關於一種苯酞類化合物用於製備治療阿茲海默症及2,3-二磷酸甘油酸代謝異常所導致的病症之醫藥組合物的用途,其特徵為該苯酞類化合物係可發揮與2,3-二磷酸甘油酸相似之調節血紅蛋白使其對氧親和力降低之功效,扮演2,3-二磷酸甘油酸代用物之角色,使阿茲海默症及2,3-二磷酸甘油酸代謝異常患者在2,3-二磷酸甘油酸濃度過低時,得以維持血紅蛋白之正常釋放氧氣之組織細胞之生物功能,使細胞含氧量維持在正常範圍。
