The invention discloses a pharmaceutical composition comprising phenylephrine in a sustained-release formulation alone or in combination with another active such as an antihistamine, an analgesic, an antipyretic or a non-steroidal anti-inflammatory agent or a mixture of two or more other actives. In a preferred embodiment, the composition comprises a solid dosage form with hydroxypropyl methylcellulose and carboxymethyl cellulose sodium as a matrix for sustained release of phenylephrine. Phenylephrine is released over a prolonged period of time by the solid dosage form essentially independent of pH.本發明揭示一種醫藥組合物，其包括單獨的呈持續釋放調配物形式的脫羥腎上腺素或其與另一活性物例如抗組織胺、鎮痛藥、退熱藥或非類固醇抗炎藥劑或兩種或更多其他活性物之混合物之組合。在一較佳實施例中，該組合物包括以羥丙基甲基纖維素及羧甲基纖維素鈉為基質以持續釋放脫羥腎上腺素之固體劑型。脫羥腎上腺素係藉由實質與pH無關之固體劑量型釋放一段經延長時間。
