5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors

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专利权人:

LEO Pharma A/S

发明人:

Mogens Larsen,Andreas Ritzen,Bjarne Nørremark,Daniel Rodriguez Greve

申请号：

US16483079

公开号：

US10799507B2

申请日:

2018.02.01

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention relates to a compound according to formula (I)wherein X represents NH or O； n is an integer selected from 1-3； Y represents a bond, —；C(O)O—；*, —；C(O)OR3—；* or —；C(O)NHR3—；*； W is selected from the group consisting of phenyl, pyridyl, (C3-C7)cycloalkyl and 4-6 membered heterocycloalkyl； or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

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