The presently-disclosed subject matter includes methods for treating Alzheimers disease in a subject. The subject can have Alzheimers diseases, can be identified has being at risk for developing Alzheimers disease, or both. The method can comprise administering a composition that includes a CD33 inhibitor, which may include a CD33 antibody. In some embodiments the composition can further comprise at least one additional component useful for treating Alzheimers disease. The presently-disclosed subject matter also includes compositions and kits for treating Alzheimers disease in a subject.
