Methods of making room temperature-curable polymers. Reactants include siloxane-terminated polymers and silanols. The reactants are mixed, and the polymerization allowed to proceed in air at room temperature. The polymers are exceptionally useful because they allow for the incorporation into the polymers themselves of one or more therapeutic compounds. Thus, medical devices from which controlled drug release is desirable (for either local or systemic delivery) can be coated with therapeutic compound-containing polymers of the invention. In a preferred embodiment, a polymer of poly(MPC w :LAM x :HPMA y :TSMA z ) where w, x, y, and z represent the molar ratios of monomers used in the feed for preparing the polymer MPC represents the unit 2-methacryoyloxyethylphosphorylcholine, LMA represents the unit lauryl methacrylate, HPMA represents the unit 2-hydroxypropyl methacrylate, and TSMA represents the unit 3-trimethoxysilylpropyl methacrylate is reacted with polydimethylsiloxane. In another preferred embodiment, a therapeutic compound is incorporated into the polymer, such as dexamethasone.本發明係關於製造室溫可固化聚合物之方法。反應物包括矽氧烷端基聚合物及矽烷醇。將反應物混合且允許其在空氣中於室溫下進行聚合反應。此聚合物可併合一或多種治療化合物。因此,可將希望控制藥物釋放(局部或全身遞送)之醫療裝置用含有治療化合物之本發明聚合物塗佈。在一較佳實施例中,使聚(MPCw:LAMx:HPMAy:TSMAz)之聚合物(其中w、x、y及z表示用於製備聚合物之進料中所使用之單體的莫耳比;MPC表示2-甲基丙烯醯氧基乙基磷酸膽鹼單元,LMA表示甲基丙烯酸月桂酯單元,HPMA表示甲基丙烯酸2-羥丙酯單元,且TSMA表示甲基丙烯酸3-三甲氧基矽烷基丙酯單元)與聚二甲基矽氧烷反應。在另一較佳實施例中,將諸如地塞米松(dexamethasone)之治療化合物併入聚合物中。
