An one-time self-destructive safe syringe, including a putter and a syringe barrel, wherein one end of the putter is sleeved with a piston, the piston is internally combined with a flexible protrusion, and the protrusion front end protrudes from the piston top surface at a distance. The syringe barrel has a front and a rear ends, wherein the front end facilitates the injection after the putter is placed therein, and the rear end shrinks toward the inner diameter to form a socket part for binding the needle, the inner wall of the socket part is provided with a latching part, so that when the putter is pushed close to the rear end of the syringe barrel, the front end of the protrusion can enter the socket part to be limited at the latching part of the inner wall of the socket part, thus becoming restricted within the socket part. Also, the protrusion has at least one perforation for buffering the insertion force of the protrusion front end into the socket part in order to allow the putter to be departed from the piston and removed when the putter is pulled back.一種一次性安全自毀針筒,包括一推桿與一針筒筒身。其中該推桿一端套合有一活塞,而該活塞內結合有一具有彈性之突柱,且該突柱前端係突出該活塞頂面有一距離,該針筒筒身具有前、後兩端,其中前端供推桿置入後進行注射,而後端向內徑縮形成一供針頭結合之插座部,且該插座部內壁則設有一卡部,藉以使推桿被推到靠近針筒筒身後端時,該突柱前端可進入插座部而受限於插座部內壁之卡部,而限制於插座部內,且該突柱上係設有至少一穿孔,藉以使緩衝突柱前端進入插座部時之力量,而回拉該推桿時,該推桿可脫離活塞而取出。1...推桿2...針筒筒身22...後端221...插座部222...卡部3...活塞4...突柱41...翼部42...穿孔