The present invention provides a method for manufacturing derivatives of thiabenzoazulene propionic acid, the derivatives of thiabenzoazulene propionic acid can be used as an effective ingredients for antihistamine agent. According to the manufacturing method of present invention could manufacture derivatives of thiabenzoazulene propionic acid which the second position of the thiabenzoazulene skeleton was substituted by propionic acid. The synthesized derivatives of thiabenzoazulene propionic acid possessing excellent histamine H1 receptor antagonistic action, and also exhibiting low intracerebral transitivity, can be used as an effective ingredients of pharmaceutical compositions such as antihistamine agent.本發明提供一種硫苯並薁丙酸衍生物之製造法,該硫苯並薁丙酸衍生物可使用作為抗組織胺劑等之有效成分。如依本發明之製造法即可製造硫苯並薁骨架的2位經丙酸取代之化合物的硫苯並薁丙酸衍生物,經合成之硫苯並薁丙酸衍生物除了具有優異之組織胺H1受體拮抗作用,並顯現低的腦內遷移性,可使用作為抗組織胺劑等之醫藥組成物的有效成分。
