Crystalline forms of acid (S, e) - 4 - (2 - (3 - (3 - Chloro - 2-fluoro-6 - (1h tetrazole - 1 - il) phenyl) acryloyl) - 5 - (4 - methyl - 2 - oxopiperazin - 1 - il) - 1,2,3,4 - tetrahidroisoquinolin - 1 - carboxamide) benzoic acid； Preparation Process； Pharmaceutical Composition and use in the treatment of thromboembolic Disorders such as ang INA, myocardial infarction, Stroke, Thrombophlebitis, among others.

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专利权人:

BRISTOL-MYERS SQUIBB COMPANY.

发明人:

DABROS MARTA,WEI CHENKOU

申请号：

CL2015000916

公开号：

CL2015000916A1

申请日:

2015.04.10

申请国别(地区):

CL

年份:

2015

代理人:

摘要：

The instant invention provides crystalline forms of (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid and its solvates thereof； processes for the production of such crystalline forms； pharmaceutical compositions comprising such crystalline forms； and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.FORMAS CRISTALINAS HCL:SA-1, H.5-1 Y P13 DEL ÁCIDO (S,E)-4-(2-(3-(3-CLORO-2-FLUORO-6-(1H-TETRAZOL-1-IL)FENIL)ACRILOIL)-5-(4-METIL-2-OXO PIPERAZIN-1-IL)-1,2,3,4-TETRAHIDROISOQUINOLIN-1-CARBOXAMIDA)BENZOICO； COMPOSICIONES FARMACÉUTICAS； Y SU USO PARA TRATAR TRASTORNOS TROMBOEMBÓLICOS.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/