antibody, method for producing the antibody, nucleic acid molecule, method for treating a disease, use of an antibody, and method for producing an antigen binding domain
Adam William Clarke,Andrew James Pow,Anthony Gerard Doyle,Bernadete Wai,Lynn Dorothy Poulton,Philip Antony Jennings
申请号：
BRPI0917668
公开号：
BRPI0917668A2
申请日:
2009.08.14
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R β2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL- 12p80 to human IL-12Rβ1.
