4- (Pyridin-4-yl) -1H- (1,3,5) triazin-2-one derivatives as GSK3-beta inhibitors for the treatment of neurodegenerative diseases

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专利权人:

サノフイ;田辺三菱製薬株式会社

发明人:

ロチード，アリステア,サデイ，ムラ,イエシユ，フイリツプ,ロチード,アリステア,サデイ,ムラ,イエシユ,フイリツプ

申请号：

JP2011515667

公开号：

JP5581318B2

申请日:

2009.06.25

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

A triazinone derivative represented by formula (I) wherein: wherein: Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C 1-6 alkyl group, a hydroxyl group, a C 1-6 alkoxy group； R1 represents a 4-pyridine ring； R2 represents a hydrogen atom, a C 1-6 alkyl； R3 represents a hydrogen atom, a C 1-6 alkyl group； R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted； R4 represents: a phenyl ring, being optionally substituted； n represents 0 to 2； in form of a free base or of an addition salt with an acid. These compounds are useful as GSK3-² inhibitors.

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