GRIFFITH DAVID ANDREW,DOW ROBERT LEE,SOUTHERS JAMES ALFRED JR.,EDMONDS DAVID JAMES
申请号：
NZ61615612
公开号：
NZ616156A
申请日:
2012.04.09
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed are pyrazolospiroketone derivatives for use as acetyl-CoA carboxylase inhibitors of general Formula (I) wherein the substituents are as described in the specification. Also disclosed is the use of the compounds in manufacturing a medicament for treating obesity and obesity related diseases such as Type 2 diabetes by inhibiting fatty acid synthesis and by increasing fatty acid oxidation. Examples of the compounds of formula (I) are: 6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1&rsquoH-spiro[indazole-5,4&rsquo-piperidin]-1&rsquo-yl)carbonyl]-1H-indole-3-carboxamide and 1&rsquo-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-1-isopropyl-1,4-dihydrospiro[indazole-5,4&rsquopiperidin]-7(6H)-one and 5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1&rsquoH-spiro[indazole-5,4&rsquo-piperidin]-1&rsquo-yl)carbonyl]-1H-indazole-3-carboxamide
