Thomas L. Chenevert;Elif A. Oral;Hero K. Hussain;Charles F. Burant;Barbara J. McKenna
发明人:
Elif A. Oral,Charles F. Burant,Thomas L. Chenevert,Hero K. Hussain,Barbara J. McKenna
申请号：
US12995842
公开号：
US08501686B2
申请日:
2009.06.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention generally relates to the use of leptin in the treatment of a leptin-responsive disease or condition in a non-lipodystrophic subject. More particularly, the invention is directed to the use of leptin in the treatment of a fatty liver disease in a non-lipodystrophic subject with a relative leptin deficiency. The invention includes methods for the treatment of nonalcoholic steatohepatitis (NASH), alcoholic fatty liver disease (AFLD), and nonalcoholic fatty liver disease (NAFLD) in a non-lipodystrophic subject. The invention includes the treatment of conditions ranging from ectopic lipid accumulation (steatosis) to cirrhosis.
