COLLADO, ANA MORENO;KATREKAR, DHRUVA;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MALI, PRASHANT
发明人:
MALI, PRASHANT,KATREKAR, DHRUVA,COLLADO, ANA MORENO
申请号：
CA3034089
公开号：
CA3034089A1
申请日:
2017.08.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present disclosure relates to a novel delivery system with unique modular CRISPR-Cas9 architecture that allows better delivery, specificity and selectivity of gene editing. It represents significant improvement over previously described split-Cas9 systems. The modular architecture is "regulatable". Additional aspects relate to systems that can be both spatially and temporally controlled, resulting in the potential for inducible editing. Further aspects relate to a modified viral capsid allowing conjugation to homing agents.
