Use of a compound of [3 - (1 - (1h imidazole - 4-yl) ethyl] - 2-methylphenyl] methanol for preparing Medicine useful for reducing intraocular pressure, article of manufacture, and Pharmaceutical composition comprising it
Using a methane compound containing formula (1) [3 - (1 - (1h-imidazol-4-il) ethyl) - 2-methylphenyl],(2) Or (3),Its individual enantiomers, diastereomers, hydrates, solutions, crystal forms, individual isomers, monomeric ceramic photometers or pharmaceutical salts. Among them, R1 is h or c1-3 tar； R2 is h or c1-3 tar； R3 is h, C1-10 tar, heterocycle or arilo； R is C1-10 tar, heterocycle or arilo； it can be used to manufacture drugs to reduce the pressure in the eyes. Product and pharmaceutical ingredients, including requirement 6 of this compound: use in accordance with requirement 2,characterized in that the compound is selected from: iso-butyric acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester； 2,2-Dimethyl-propionic acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester； Acetic acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester； Benzoic acid ester 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl； 3-Methyl-butyric acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester； 3-Phenyl-propionic acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester； 2-Amino-3-methyl-butyric acid 3 - [(S) -1- (1H-imidazol-4-yl) -ethyl] -2-methyl-benzyl ester；Benzene of 1 - (1 -) (1 - (1 -) (1 - (1 -) (1 -- 2-methyl-2-amino-3-phenyl-propane).Uso de un compuesto de [3-(1-(1H-imidazol-4-il)etil)-2-metilfenil]metanol que tiene la fórmula (1), (2) ó (3), sus enantiómeros individuales, sus diastereoisómeros, sus hidratos, sus solvatos, sus formas cristalinas, sus isómeros individuales, sus tautómeros individuales o una sal farmacéuticamente. aceptable de la misma, donde R1 es H o alquilo C1-3； R2 es H o alquilo C1-3； R3 es H, alquilo C1-10, heterociclo o arilo； y R es alquilo C1-10, heterociclo o arilo； para preparar un medicamento útil para la reducción de la presión intraocular. Artículo de fabricación y composición farmacéutica que comprenden dicho compuesto.Reivindicación 6: El uso de acuerdo con la reivindi
