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Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation
专利权人:
Satoshi Minakami;Hiroyuki Tokumitsu;Kotoe Ohta
发明人:
Kotoe Ohta,Satoshi Minakami,Hiroyuki Tokumitsu
申请号:
US12600021
公开号:
US09084817B2
申请日:
2008.05.20
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A chemically stable oral preparation with an excellent dissolution property comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof is disclosed. The oral preparation according to the present invention comprises a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof as an effective ingredient and an organic acid, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20° C. The method for improving dissolution property and chemical stability of an oral preparation according to the present invention comprises incorporating an organic acid in the oral preparation comprising as an effective ingredient a specific morphinan derivative or a pharmaceutically acceptable acid addition salt thereof, wherein 1 g of said organic acid requires not less than 30 mL of water to dissolve in at 20° C.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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