The present invention relates to a transdermal therapeutic system for the transdermal administration of guanfacine comprising a guanfacine-containing layer structure, said guanfacine-containing layer structure comprising:A) a backing layer; andB) a guanfacine-containing layer;wherein the transdermal therapeutic system comprises at least one polymer and at least one additive.本發明關於用於經皮投予胍法辛(guanfacine)之經皮治療系統,其包括含胍法辛之層結構,該含胍法辛之層結構包括:A) 背襯層;及B) 含胍法辛之層;其中該經皮治療系統包括至少一種聚合物及至少一種添加劑。