TRON TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBE;BIONTECH RNA PHARMACEUTICALS GMBH
发明人:
Ugur Sahin,Tim Beissert,Marco Poleganov,Stephanie Herz,Lars Koste
申请号：
US16245353
公开号：
US20190269793A1
申请日:
2019.01.11
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to expressing RNA in cells and, in particular, enhancing viability of cells in which RNA is to be expressed. Specifically, the present invention provides methods for expressing RNA in cells comprising the steps of preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells. Thus, preventing engagement of IFN receptor by extracellular IFN and inhibiting intracellular IFN signalling in the cells allows repetitive transfer of RNA into the cells.
