AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
Yong Sung KIM,Keunok JUNG,Ji Hee HA,Ye Jin KIM,Dong Ki CHOI,Hye Ji CHOI
申请号：
MX2019001651
公开号：
MX2019001651A
申请日:
2017.08.10
申请国别(地区):
MX
年份:
2019
代理人:
摘要：
The present invention relates to a heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein, wherein in the heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of a Fc region pair of an immunoglobulin while a subunit of a biologically active protein is bound to at least one of N-terminal or C-terminal of the first Fc region and/or the second Fc region, the first Fc region and the second Fc region are CH3 domains modified to promote the formation of a heterodimer. In the heterodimeric Fc-fused protein according to the present invention, two or more subunits form a protein complex, so that a protein constituting a biologically active protein can be fused to Fc in an original shape and structure as the protein exists in nature and thus the protein can maintain an original activity as the protein exists in nature. The use of the heterodimeric Fc-fused protein according to the present invention remarkably increases the in vivo half-life of a biologically active protein contained in the heterodimeric Fc-fused protein, and thus various types of biological activities can be maintained for a long time in the body.La presente invencion se refiere a una proteina fusionada a un Fc heterodimerico que comprende una primera region de Fc y una segunda region de Fc de un par de Fc de inmunoglobulina y una proteina fisiologicamente activa compuesta de dos o mas subunidades diferentes, en donde una o mas subunidades de la proteina fisiologicamente activa son enlazadas por separado a uno o mas extremos del extremo N-terminal o C-terminal de la primera region de Fc y/o la segunda region de Fc, y los dominios CH3 de la primera region de Fc y la segunda region de Fc son mutados a fin de promover la formacion del Fc heterodimerico； ademas, la presente invencion se refiere a una composicion farmaceutica que comprende la proteina fusionada al Fc heterodimerico； la proteina fusionada al Fc heterodimerico de co
