WILLIAM J BINDER,バインダー，ウイリアム，ジェイ．,バインダー,ウイリアム,ジェイ.
申请号：
JP2017094987
公开号：
JP2017160249A
申请日:
2017.05.11
申请国别(地区):
JP
年份:
2017
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide therapeutic methods of migraine and diseases associated with it.SOLUTION: The present invention provides a therapeutic method of a patient with migraine including symptoms associated with migraine, such as migraine-associated vertigo, the method comprising administering a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmacologically safety form, for example, botulinum toxin, to a patient. The method is performed against a trigeminal nerve-cervix system so that the neurotoxin can be transported from a distal site to a central site. The administration is performed by extramuscularly injecting a neurotoxin to the aponeurosis/fascia of the scalp so that the neurotoxin can be diffused in a distal sensory nerve in order to allow it to concentrate in the occipital region-parietal region-frontal region. The method comprises intraorally and extramuscularly injecting the neurotoxin to the ganglial hole so that the neurotoxin can be diffused in the ganglion pterygopalatine, and the administration is performed against the trigeminal nerve-cervix system so as to enable the axonal transport of the neurotoxin from a distal site to a central site.SELECTED DRAWING: Figure 1【課題】片頭痛およびそれに関連する病気の治療方法を提供。【解決手段】患者に治療的有効量の薬学的に安全な形態の無脊椎動物シナプス前部神経毒、例えばボツリヌス毒素を投与することを含む、片頭痛関連めまいなどの片頭痛に関連する症状を含む片頭痛を有する患者の治療方法。本神経毒を遠位から中心部位に輸送できるように、三叉神経－頸部系に対して行い、該投与は、後頭部－頭頂部－前頭部に集中させるために、本神経毒が遠位感覚神経に拡散できるように、神経毒を頭皮の腱膜／筋膜に筋肉外注射する。本神経毒が翼口蓋神経節に拡散できるように、本神経毒をこの神経節の孔に口腔内筋肉外注射することを含み、かつ該投与は、本神経毒を遠位から中心部位に軸索輸送可能にするために、三叉神経－頸部系に対して行う。【選択図】図１
