Humanized anti-trkA antibodies with animo acid substitutions

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专利权人:

GLENMARK PHARMACEUTICALS SA

发明人:

BLEIN STANISLAS,OLLIER ROMAIN,SKEGRO DARKO

申请号：

AP201408145

公开号：

AP201408145A0

申请日:

2013.06.07

申请国别(地区):

AP

年份:

2014

代理人:

摘要：

The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region, a light chain, variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.

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中国工程科技知识中心

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http://www.ckcest.cn/home/