PROTTER, ANDREW ASHER,CHAKRAVARTY, SARVAJIT,JAIN, RAJENDRA PARASMAL,GREEN, MICHAEL JOHN
申请号：
EP12782062
公开号：
EP2675459A4
申请日:
2012.02.17
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor &alpha；2B antagonists. The compounds may also bind to and antagonize adrenergic receptor &alpha；1B. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.
