A method for the prevention of hypoglycaemia in diabetes mellitus type 2 comprising administering (a) desPro36Exendin-4(1-39)-Lys6-NH2 or/and a pharmaceutically acceptable salt thereof, and (b)a sulfonyl urea or/and a pharmaceutically acceptable salt thereof, to a subject in need thereof.一種預防第2型糖尿病中低血糖的方法,其包括將(a)desPro36艾塞那肽-4(1-39)-Lys6-NH2或/及其製藥上可接受之鹽,及(b)磺醯脲或/及其製藥上可接受之鹽給藥至需要的患者。