Dihomo-gamma-linolenic acid (DGLA) or a composition comprising DGLA for use in the prophylaxis of allergic disease in the offspring of mammalian subject wherein said DGLA is administered to said subject pre-pregnancy and/or during pregnancy and/or during lactation.用於預防哺乳動物個體後代之過敏性疾病的二均-γ-次亞麻油酸(Dihomo-gamma-linolenic acid;DGLA)或包含DGLA之組成物,其中該DGLA係在妊娠前、及/或在妊娠期間、及/或在哺乳期間向該個體投予。