PLATTEEUW JOHANNES JAN,COELINGH BENNINK HERMAN JAN TIJMEN
申请号：
IN201717011382
公开号：
IN201717011382A
申请日:
2017.03.30
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight between 50 and 1 000 mg said dosage unit consisting of: 5 100 wt.% of coated particles comprising 50 99 wt.% of a core particle and 1 50 wt.% of a coating that envelops the core particle said coating consisting of: 0.01 10 wt.%) of a partus control substance selected from oxytocin carbetocin atosiban and combinations thereof 5 50 wt.%) of buffering agent 15 80 wt.%) of branched glucan 0 78 wt.%) of other pharmaceutically acceptable ingredients 0 95 wt.%) of one or more pharmaceutically acceptable excipients the solid dosage unit comprising at least 20 µg of the partus control substance and having a pH buffer range of 3.5 5.7. The solid dosage unit of the present invention is easy to manufacture and perfectly suited for sublingual buccal or sublabial administration. Furthermore the dosage unit does not need to be stored and distributed under temperature controlled conditions.
