Chen, Haibin,Sproul, Tim W.,Hu-Lowe, Dana Dan,Tanamachi, Dawn M.,Wickman, Grant,Yang, Lan,Brams, Peter,Li, Gang,Casperson, Gerald Fries,Huang, Haichun,North, Michael Aidan,Bender, Steven Lee,Devaux, B
申请号：
AU2009212442
公开号：
AU2009212442C1
申请日:
2009.02.04
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5βl antibodies or antigen binding portions thereof described herein.
