Jenny Jie Yang,Zhiren Liu,Shunyi Li,Yubin Zhou,Jie Jiang,Shenghui Xue,Jingjuan Qiao,Lixia Wei
申请号：
US14405623
公开号：
US20150202330A1
申请日:
2013.06.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided is a protein contrast agent for enhancing an MRI image and comprising a polypeptide having a conformation presenting at least five oxygen atoms positioned to chelate at least one paramagnetic metal ion such as Gd3+, each oxygen atom being between about 2 angstrom units and about 5 angstrom units from the metal ion the metal ion has at least one water molecule electrostatically interacting a distance of less than about 10 angstrom units a target-specific moiety conjugated thereto, at least one polyethylene glycol molecule, and a paramagnetic metal ion. Also provided is a method of obtaining an enhanced MRI image using the protein contrast agent to a T2/T1 or T1/T2 intensity ratio of the MRI image and (d) obtaining an image of the T2/T1 or T1/T2 intensity ratio.
