A specimen retrieval system for use with minimally invasive surgical procedures is disclosed. The system permits excised tissue having a dimension, a size, a shape, or a volume larger than a natural orifice or a surgical incision used in a minimally invasive procedure to access the surgical site, to be removed from the body through the natural orifice or surgical incision. The system comprises a specimen retrieval container and a compression structure. The compression structure is configured to apply a compressive force to the container to reduce or alter at least one of a dimension, a size, a shape, and a volume of the container and the tissue contained therein, such that the tissue can be removed through the natural orifice or surgical incision without need to surgically alter or enlarge the orifice or original incision.
