AN IMPROVED PROCESS FOR THE PREPARATION OF CHIRAL DIOL SULFONES AND HMG-COA REDUCTASE INHIBITORS

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专利权人:

发明人:

DWIVEDI SHRIPRAKASH DHAR,PATEL DHIMANT JASUBHAI,RUPAPURA MAHESH LALJIBHAI

申请号：

IN3028/MUM/2009

公开号：

IN2009MU03028A

申请日:

2009.12.30

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

The present invention relates to a novel process for the preparation of chiral diol sulfones of general formula (1), in particular to l-tert-butoxy-3-((4R,6S)-2,2-dimethyl-6-((l-phenyl-lH-tetrazol-5-ylsulfonyl)methyl)-l,3-dioxan-4-yl)propan-2-one of formula (2), which is the key intermediate for the production of the HMG-CoA reductase inhibitors like Rosuvastatin, Atorvastatin, Pitavastatin, and the like. where R is as shown below where R1 is preferably aryl such as phenyl.

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