The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided comprising 10 or more capsular saccharides from different S. pneumoniae serotypes which are conjugated to a carrier protein, and comprising 3 or more different carrier proteins, wherein the composition comprises: serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT)； serotype 18C capsular saccharide conjugated to tetanus toxoid (TT)； serotype 1,4,5,6B,7F,9V,14 and 23F capsular saccharides conjugated to protein D from Haemophilus influenzae .
