A fully-automatic regional citrate anticoagulation machine is disclosed. A sampling portion extracts a blood sample on line and in real time and sends it to a storage purifier for storage and purification. A sample injection portion conveys the blood sample in the blood sample storage purifier to a sample loading slot through a sample injection tube. An assay and analysis portion conveys, through a sample suction tube, the blood sample to an analyzer for blood sample assay and analysis. The sampling portion, the sample injection portion, the assay and analysis portion and an administration portion are connected to the program control portion. The program control portion controls, according to an internally-set program, operation of the sampling portion, the sample injection portion and the assay and analysis portion, and sends an instruction to the administration portion according to the data result obtained by the assay and analysis portion.
