PROBLEM TO BE SOLVED: To provide tetomilast crystals that can easily be produced in an industrially large scale.SOLUTION: The mixture of (1) a tetomilast hydrate crystal having an X-ray powder diffraction spectrum substantially same as that of Figure 2, (2) a tetomilast anhydride A type crystal having an X-ray powder diffraction spectrum substantially same as that of the Figure 4, (3) a tetomilast anhydride C type crystal having an X-ray powder diffraction spectrum substantially same as that of Figure 8, (4) a tetomilast acetonitrile crystal having an X-ray powder diffraction spectrum substantially same as that of Figure 10. A mixture of (5) the tetomilast anhydride A type crystal and the tetomilast anhydride B type crystal is stable to heat and humidity and has excellent disintegration property and elution property and can suitably be used as a pharmaceutical composition.COPYRIGHT: (C)2009,JPO&INPIT【課題】本発明は、工業的に大量生産しやすいテトミラスト結晶を提供する。【解決手段】(1)図2と実質的に同じ粉末X線回折スペクトルを有するテトミラスト水和物結晶、(2)図4と実質的に同じ粉末X線回折スペクトルを有するテトミラスト無水物A形結晶、(3)図8と実質的に同じ粉末X線回折スペクトルを有するテトミラスト無水物C形結晶、(4)図10と実質的に同じ粉末X線回折スペクトルを有するテトミラストアセトニトリル和物結晶及び(5)前記テトミラスト無水物A形結晶及びテトミラスト無水物B形結晶との混合物は、熱及び湿度に対して安定で、かつ、錠剤の崩壊性及び溶出性の点において優れており、医薬組成物として好適に使用される。【選択図】なし
