The present disclosure relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human Factor XI and activated Factor XI (“Factor XIa”), as well as pharmaceutical compositions and methods of treatment containing them.本開示は、ヒト第XI因子および活性型第XI因子(「第XIa因子」)に結合するモノクローナル抗体およびその抗原結合性断片、ならびにこれらを含む医薬組成物および処置方法に関する。