in vitroin vivoThe invention comprises a composition comprising a bioerodible porous silicon based carrier material wherein the carrier material carries at least one large molecule therapeutic agent and at least one amorphous sugar optionally further comprising a crystallization inhibitor. The composition may be used or to deliver the therapeutic agent preferably in a controlled fashion over an intended period of time such as over multiple days weeks or months. The composition may be used for treating or preventing conditions of a patient such as chronic diseases.