Process for preparing an anti-cancer agent, 1-((4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl) cyclopropanamine, its crystalline form and its salts

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专利权人:

LLC;Advenchen Pharmaceuticals;Advenchen Pharmaceuticals, LLC;Guoqing Chen

发明人:

Chen, Guoqing Paul,Yan, Changren

申请号：

AU2016257816

公开号：

AU2016257816A1

申请日:

2016.05.03

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The present invention relates a new process to synthesize 1-((4-(4-Fluoro-2-methyl-1H- indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine (AL3818). A stable crystalline form of A13818 has been prepared. Salts and their crystalline forms of AL3818 have been also prepared. Anti-cancer and optometric activities of AL3818 and its salts have been further tested. New process has been outlined in Scheme I.

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中国工程科技知识中心

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