PROBLEM TO BE SOLVED: To provide a novel promoter which can exhibit ON-type bipolar cell-specific transcriptional activity in a small size.SOLUTION: The invention provides a DNA which consists of a base sequence identical or substantially identical to a specific base sequence or a partial base sequence thereof containing at least proximal Otx2 junction sequence, and which has an ON-type bipolar cell specific transcriptional activity and a vector comprising a promoter which consists of the DNA. By linking a gene for prevention and/or treatment to downstream of the vector and administering to a mammalian retina, prevention and/or treatment of hereditary retinal disorder or retinopathy accompanied by degeneration of visual cells is enabled.COPYRIGHT: (C)2015,JPO&INPIT【課題】小さなサイズでON型双極細胞特異的な転写活性を発揮し得る新規プロモーターの提供。【解決手段】特定の塩基配列、もしくは少なくとも近位Otx2結合配列を含むその部分塩基配列と、同一もしくは実質的に同一の塩基配列からなるDNAであって、ON型双極細胞特異的な転写活性を有するDNA。該DNAからなるプロモーターを含んでなるベクター。該ベクターの下流に予防及び/又は治療用遺伝子を連結して哺乳動物網膜に投与することにより、遺伝性網膜疾患又は視細胞変性を伴う網膜疾患の予防及び/又は治療が可能となる。【選択図】なし
