A chronic wound management apparatus fitted to at least some teeth of a patient's upper or lower arch is provided for the application of medications to the teeth and to adjacent gum tissue and for compression of said tissue for treatment of a chronic wound of the periodontal tissue. The apparatus includes at least one recess formed to conform to the teeth. A seal surrounds the recess at a location corresponding to the patient's gum line for applying pressure at the patient's gum line when the patient's teeth are disposed in the recess. A wound compression extension extends from the seal. Methods for treating chronic wounds of the periodontal tissue and for making the apparatus are also disclosed.