THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
XIE, XUPING,SHAN, CHAO,SHI, PEI-YONG
申请号：
CA3053289
公开号：
CA3053289A1
申请日:
2018.02.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention discloses a live attenuated strain of Zika virus (ZIKV) having a deletion in the 3' untranslated region (3'UTR) of the viral genome, which may affect viral RNA synthesis and sensitivity to type I interferon inhibition, but may not affect viral RNA translation. The present invention also discloses the use of these live attenuated ZIKV strains in the preparation of ZIKV vaccines and for providing immunoprotection against ZIKV infection and congenital ZIKV syndrome, particularly in pregnant females.
