CELLULES GENETIQUEMENT MODIFIEES EXPRIMANT UN ANTIGENE MEMBRANAIRE SPECIFIQUE DE LA PROSTATE (PSMA) OU UNE FORME MODIFIEE DE CELUI-CI ET PROCEDES ASSOCIES
THE JOHNS HOPKINS UNIVERSITY;JUNO THERAPEUTICS, INC.
发明人:
HUSS, DAVID JEFFREY,LEVITSKY, HYAM I.,MINN, IL,POMPER, MARTIN G.
申请号：
CA3056261
公开号：
CA3056261A1
申请日:
2018.04.07
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Provided are cells, such as engineered cells, that express a prostate-specific membrane antigen (PSMA) or a modified form thereof. In some embodiments, the cell further contains a genetically engineered recombinant receptor, such as a chimeric antigen receptor, that specifically binds to an antigen. The present disclosure also provides methods of detecting, identifying, selecting or targeting cells expressing PSMA, such as in connection with administration of such cells to subjects, including methods of adoptive cell therapy, or in connection with methods of manufacturing engineered cells.
