METHODE DE PREPARATION DE DERIVES DE 7H-PYRROLO[2,3-D]PYRIMIDINE ET DE SES CO-CRISTAUX

• 收藏
• 分享

专利权人:

JAPAN TOBACCO INC.

发明人:

SHIMAZAKI, TAKAHISA

申请号：

CA3044796

公开号：

CA3044796A1

申请日:

2017.12.20

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present invention relates to: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitor； a cocrystal of the derivative； a method for producing the cocrystal； and a method for purifying the 7H-pyrrolo[2,3-d]pyrimidine derivative using the cocrystal. The present invention provides a method for producing, for example, 3-[(3S,4R)-3-methyl-6(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile, wherein use is made of a cocrystal of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile with 3,5-dimethylpyrazole.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/