The present invention relates to the lyophilizing moulding article, contain 〉=one or more active substances of 50 weight %, form agent with one or more supports of≤15 weight %, wherein except the protein quilt, and one or more auxiliary substances randomly, every kind of situation is all based on total composition of lyophilizing moulding article, and the solution of its 1 weight % in water or suspension are 20 ℃ of following pH value<7.Further, the present invention relates to the preparation method of these lyophilizing moulding articles, described lyophilizing moulding article is with the combination of aqueous solution in the kit structure, and lyophilizing moulding article and kit combination are used for medicinal and purposes cosmetic application.