Conjugates which comprise a drug and a ligand which includes a first saccharide wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.薬物と第一の糖を含むリガンドとを含む複合体であって、該複合体を哺乳類に投与したとき、少なくとも1つの複合体の薬物動態または薬力学的特性が、第二の糖の血清濃度に対し感受性を示すことを特徴とする複合体。例示的な複合体および徐放性製剤が、使用および調製方法に加えて提供される。【選択図】なし
