The 2 of bardoxolone methyl,2- difluoros propanamide derivative, its polymorph and application method农业专利-农业学术服务平台

专利权人:: 里亞塔醫藥公司; Inc.;Reata Pharmaceuticals;里亚塔医药公司;Reata Pharmaceuticals, Inc.

发明人:: ANDERSON, Eric,埃里克．安德森,DECKER, Andrea,安德里亚．德克尔,安德里亞．德克爾,LIU, Xiaofeng,刘晓峰,劉曉峰,埃里克.安德森,安德里亚.德克尔,安德里亞.德克爾

摘要：: The present invention relates generally to following compounds: N- ((4aS,6aR,6bS,8aR,12aS,14aR,14bS) cyano-2-11-,2,6a,6b,9,9,Seven methyl-1s 0 of 12a-,Dioxo -1 14-,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,Ten Ba Qing Pi -4a- bases of 14b-) -2,Bis- fluoroalanines of 2-, its polymorph, its preparation and application, its pharmaceutical composition and its kit and product.本發明大體上涉及以下化合物：N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-氰基-2,2,6a,6b,9,9,12a-七甲基-10,14-二氧代-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-十八氫苉-4a-基)-2,2-二氟丙酰胺、其多晶型物、其製備和使用方法、其藥物組合物以及其試劑盒和製品。