METHODS OF TREATING CANCERS, IMMUNE AND AUTOIMMUNE DISEASES, AND INFLAMMATORY DISEASES BASED ON BTK OCCUPANCY AND BTK RESYNTHESIS RATE农业专利-农业学术服务平台

发明人:: LANNUTTI, BRIAN,雷努提布莱恩,雷努提布萊恩,COVEY, TODD,克维陶德,克維陶德,KAPTEIN, ALLARD,卡特恩阿拉德,卡特恩阿拉德,JOHNSON, DAVID,强森大卫,強森大衛,STAMATIS, JAY,史塔玛提斯杰,史塔瑪提斯傑,KREJSA, CECILE M.,克瑞萨瑟希尔,克瑞薩瑟希爾,SLATTER, JOHN GREGORY

摘要：: In an embodiment, therapeutic methods and use of a Bruton’s Tyrosine Kinase (BTK) inhibitor for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for a BTK inhibitor for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described.在一實施態樣中,本發明說明布魯頓(Bruton)氏酪胺酸激酶(BTK)抑制劑以多種不同疾病和組織室(其包括骨髓及淋巴結)中的B細胞之BTK佔據及/或BTK再合成速率為基礎之治療癌症、發炎、免疫病症和自體免疫病症及移植預防之治療方法及用途。在一實施態樣中,本發明說明BTK抑制劑以多種不同疾病和組織室(其包括骨髓及淋巴結)中的B細胞之BTK佔據及/或BTK再合成速率為基礎之治療癌症、發炎、免疫病症和自體免疫病症及移植預防之給藥配置。