A method and composition are presented for enhancing the dissolution andbioavailable properties of CoQ10 nutritional supplements and/or therapeuticagents for a human being and other mammals. The method includes preparing ananhydrous self~microemulsifying base composition by combining: CoQ10, a water-immiscible, and a non-ionic surfactant, containing polyethylene glycol. For anorally administered CoQ10 nutritional supplement in a capsule formulation, aunit dosage from the composition is added to a dissolvable capsule, preferablya soft gelatin capsule, in order to form the nutritional supplement. When acapsule containing the self-microemulsifying composition enters the digestivetract, the temperature of the body's digestive juices warms the composition,causing any of the CoQ10 that may have re-crystallized out of the compositionto become re-dissolved into the composition before the capsule dissolves. There-dissolution of CoQ10 is bioavailable when the capsule dissolves. Upondissolution of the capsule, the self-microemulsifying composition comes intocontact with the digestive juices and naturally forms micellar-type bioavaiblemicroemulsions, consisting of micelles containing CoQ10. In addition to thecapsule formulation, the invention includes parenteral, liquid, topical andophthalmic formulations.
