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CYCLOALKYLIDENE AND HETEROCYCLOALKYLIDENE HDAC INHIBITOR COMPOUNDS
专利权人:
GILEAD SCIENCES; INC.
发明人:
MELVIN, LAWRENCE, S
申请号:
NZ59074709
公开号:
NZ590747A
申请日:
2009.07.28
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. Examples of compounds of the invention are: 4-(1-(5-acetyl-4-methylthiazol-2-yl)cyclopropyl)-N-hydroxybenzamide N-hydroxy-4-(1-(4-(imidazo[1,2-a]pyridin-3-yl)thiazol-2-yl)cyclopropyl)benzamide N-hydroxy-4-(1-(4-(1-isopropyl-2-methylimidazol-5-yl)thiazol-2-yl)cyclopropyl)benzamide Diseases may be selected from cell proliferative disease, autosomal dominant disorder, genetic related metabolic disorder, fibrosis, autoimmune disease, diabetes, neurological disease, and Alzheimers disease.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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