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Pyrone-indole derivatives and process for their preparation
专利权人:
Moshe Laudon;Tal Peleg-Shulman
发明人:
Moshe Laudon,Tal Peleg-Shulman
申请号:
US12612001
公开号:
US08242163B2
申请日:
2009.11.04
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to a method for treating insulin resistance, neuronal loss associated with stroke, ischemia, central nervous system trauma, a central nervous system disorder, a neurodegenerative disease, the adverse consequences of the over-stimulation of excitatory amino acids, a psychiatric disease, epilepsy or other convulsive disorder, chronic pain, CMV retinitis, urinary incontinence, or for inducing anesthesia; which comprises administering to an animal or human in need thereof an effective amount of a pharmaceutical formulation comprising an effective amount of a pyrone-indole derivative of formula (I):Ar—B—Ar′  (I)wherein Ar represents an indole nucleus ring system:Ar′ represents an alpha-, beta- or gamma-pyrone nucleus ring system:and each of B, R1-4, and R1-2′ are one of the groups as defined herein.
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